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Monday, July 02, 2012

Can Caffeine Keep Away Dementia??

I drink coffee, probably too much coffee. Usually the “good” effects of coffee seem limited to 2 or 3 cups a day. But maybe there are some good side effects of a decent amount of coffee.

from http://www.medscape.org/viewarticle/766208?src=cmemp

Patients with mild cognitive impairment (MCI) may be able to avoid developing dementia by drinking several cups of coffee a day, the results of a new study suggest….

That 1200-ng/mL level appears to be an important threshold, said Dr. Arendash. The amount of coffee needed to reach this critical level appears to be 3 to 5 cups daily, with a target of 5 cups or 500 mg of caffeine. Those previous AD mouse studies showed that 1 to 2 cups, or between 100 and 200 mg of caffeine (which is what typical Americans drink daily), were not enough to ward off dementia, he said. It's not known whether it's necessary to spread those 5 cups throughout the day, he added.

Reference to full study is here: http://www.j-alz.com/issues/30/vol30-3.html 

Volume 30, Number 3, June 2012 Journal of Alzheimer’s Disease

Pages 467-474
Anthony Klugman, Declan P Naughton, Mokhtar Isaac, Iltaf Shah, Andrea Petroczi, Naji Tabet
Antioxidant Enzymatic Activities in Alzheimer’s Disease: The Relationship to Acetylcholinesterase Inhibitors